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Hotel Zephyr named No. 1 Best Hotel in San Francisco in Travel + Leisure's 2024 World's Best Awards.

San Francisco is perhaps best known as California’s home of technology. Along its city streets you'll find the offices of Airbnb, X, Instacart, and hundreds of others — not to mention Apple just a few miles outside of town.

San Francisco hotels come in a huge range of sizes, prices, and styles. In no particular order, we’ve rounded up some of the most unique hotels in San Francisco ranging from quirky boutique hotels to larger luxury options.

San Francisco is definitely a destination full of creative types, no matter the industry. This is a truly spectacular coastal city brimming with stunning architecture, history, art, all things tech, the eccentric, and more.

Overlooking the bay in San Francisco, Fisherman’s Wharf is a buzzy, happening borough, in one of California’s coolest cities. Make it your base, with our pick of its best hotels.